Biomarker (Reactive oxygen species, cAMP en cGMP) related research
Department of Pharmacology and Personalised Medicine
(University of Maastricht)
Collaboration with; Prof. Dr. Harald H. H. W. Schmidt (Professor of Pharmacology and Chair of Department of Pharmacology and Personalized Medicine), Mayra Pacheco Pachado (PhD student Department of Pharmacology and Personalized Medicine), Dr. Ana Casas (Researcher PhD Department of Pharmacology and Personalized Medicine), Alexandra Petraina (PhD Department of Pharmacology and Personalized Medicine) and Cristian Nogales (PhD Department of Pharmacology and Personalized Medicine)
In collaboration with the Department of Pharmacology and Personalized Medicine within Maastricht University, we are asking participants for their permission to draw an additional tube of blood during the medical examination. This blood will be used to develop a laboratory test to predict memory improvement due to the tested drug. This test will then allow us to identify patients in the future who will benefit the most from this drug. Relevant so-called biomarkers are also looked for in the blood. These are in particular specific proteins involved in the communication between brain cells. It is being investigated whether changes in these biomarkers are related to the memory problems.
Exosome related research
Department of Psychiatry and Neuropsychology
(University of Maastricht)
Collaboration with; Dr. Ehsan Pishva (Assistant Professor of Integrated Genomics of Neurodegenerative Disorders, Department of Psychiatry and Neuropsychology).
In a collaboration within the Department of Psychiatry and Neuropsychology, we are requesting permission for an additional tube of blood to be drawn during the medical exam/ and during the 24-week test day. This blood will be used to measure ribonucleic acid (RNA) accumulated in exosomes. Exosomes are small vesicles shed by cells in the blood. RNA regulates the production of important proteins in cells. We are particularly interested in RNA that inhibits protein production in cells, which may play a role in memory complaints.